Centre intégré universitaire de santé et de services sociaux de l’Est-de-l’Île-de-Montréal
À propos du CIUSSS
Accueil Plan du site Courrier Portail Québec
Size of text

Mendrek, Adrianna

Ph. D., Neurosciences

Researcher, Institut universitaire en santé mentale de Montréal Research Center

Associate professor, Department of psychology, Bishop University


Areas of expertise

Schizophrenia; Sex and Mental Health; Neuroimagering; Cognition; Addiction


    Adrianna Mendrek is interested in sex and gender factors that influence mental illness, as well as cognitive and emotional processes using neuroimaging technique. A. Mendrek is working with patients with schizophrenia, autism, attention disorders and drug addiction. She has shown in particular that brain activation is much greater in schizophrenic men when exposed to an emotional task, than in women.

    For more information: http://www.iforum.umontreal.ca/Forum/2005-2006/20060410/R_2.html

    Grants and awards

    • Bases neurocognitives des comportements suicidaires et homicidaires dans la schizophrénie : une étude pilote d’imagerie cérébrale fonctionnelle (chercheure principale, Bishop's University Senate Research Committee, 2014-2015).
    • Sex differences and menstrual-cycle modulation of the cognitive enhancing effect of nicotine (chercheure principale, Réseau de bio-imagerie du Québec, 2013-2014).
    • The clinical and biological correlates of cannabis craving in schizophrenia, and its treatment with trans-cranial magnetic stimulation (Co-Investigator, CIHR, 2010-2011).
    • The contribution of gender and estrogen to sex differences in neural correlates of cognitive and emotion processing in schizophrenia (Principal Investigator, CIHR, 2009-2011).
    • Brain mechanisms involved in the implementation of a self-regulatory task in children with attention deficit disorder with or without hyperactivity disorder (ADD / ADHD) and typical children (Principal Investigator, FRQS, 2009-2010).
    • The neurocognition of emotional memory: A combined ERP and fMRI (Co-Investigator, Natural Sciences and Engineering Research Council of Canada, 2008-2013).
    • Research Scholar, Junior 2 (FRQS, 2012-2014).
    • Research Scholar, Junior 1 (FRQS, 2005-2009).



    Potvin, S., Tikasz, A., & Mendrek, A. (2016). Emotionally Neutral Stimuli Are Not Neutral in Schizophrenia: A Mini Review of Functional Neuroimaging Studies. Front Psychiatry, 7, 115. Pubmed

    Juster, R. P., Almeida, D., Cardoso, C., Raymond, C., Johnson, P. J., Pfaus, J. G., Mendrek, A., Duchesne, A., Pruessner, J. C., Lupien, S. J. (2016). Gonads and strife: Sex hormones vary according to sexual orientation for women and stress indices for both sexes. Psychoneuroendocrinology, 72, 119-130. Pubmed

    Tikasz, A., Potvin, S., Lungu, O., Joyal, C. C., Hodgins, S., Mendrek, A., & Dumais, A. (2016). Anterior cingulate hyperactivations during negative emotion processing among men with schizophrenia and a history of violent behavior. Neuropsychiatric Disease and Treatment, 12, 1397-1410. Pubmed

    Orban, P., Desseilles, M., Mendrek, A., Bourque, J., Bellec, P., & Stip, E. (2016). Altered brain connectivity in patients with schizophrenia is consistent across cognitive contexts. J Psychiatry Neurosci, 41(4), 150247. Pubmed 

    Potvin, S., Lungu, O., Lipp, O., Lalonde, P., Zaharieva, V., Stip, E., Melun, J. P., Mendrek, A. (2016). Increased ventro-medial prefrontal activations in schizophrenia smokers during cigarette cravings. Schizophr Res, 173(1-2), 30-36. Pubmed


    Mendrek, A., & Mancini-Marie, A. (2015). Sex/gender differences in the brain and cognition in schizophrenia. Neurosci Biobehav Rev. Epub ahead of print. Pubmed

    Potvin, S., Tikasz, A., Dinh-Williams, L. L., Bourque, J., & Mendrek, A. (2015). Cigarette Cravings, Impulsivity, and the Brain. Front Psychiatry, 6, 125. Pubmed

    Mancini-Marie, A., Yoon, U., Jiminez, J., Fahim, C., Potvin, S., Grant, J. A., Laverdure-Dupont, D., Dube, A. A., Betrisey, C., Rainville, P., Evans, A. C., Stip, E., Mendrek, A. (2015). Sex, age, symptoms and illness duration and their relation with gyrification index in schizophrenia. Clin Schizophr Relat Psychoses. Epub ahead of print. Pubmed

    Potvin, S., Tikasz, A., Lungu, O., Dumais, A., Stip, E., & Mendrek, A. (2015). Emotion processing in treatment-resistant schizophrenia patients treated with clozapine: An fMRI study. Schizophr Res. Epub ahead of print. Pubmed

    Lungu, O., Potvin, S., Tikasz, A., & Mendrek, A. (2015). Sex differences in effective fronto-limbic connectivity during negative emotion processing. Psychoneuroendocrinology, 62, 180-188. Pubmed

    Mendrek, A. (2015). Is It Important to Consider Sex and Gender in Neurocognitive Studies? Front Psychiatry, 6, 83. Pubmed

    Juster  R-P., Hatzenbuehler, M., Mendrek, A., Pfaus, J.G., Smith, N.G., Johnson, P.J., Lefebvre-Louis, J-P. Raymond, C., Marin, M-F., Sindi, S. Pruessner, J.C. & Lupien, S.J. (2015).  Sexual orientation modulates endocrine stress reactivity.  Biological Psychiatry, 77(7):668-76.


    Mendrek, A. (2014). Existe-t-il des différences entre les hommes et les femmes en ce qui concerne les problèmes de toxicomanie? Santé mentale au Québec, 39(2):57-74.

    Champagne, J., Mendrek, A., Germain, M., Hot, P., & Lavoie, M.E. (2014). Event-related brain potentials to emotional images and gonadal steroid hormone levels: A comparison between men and women with schizophrenia. Frontiers in Psychology, 5:543.

    Poissant, H., Rapin, L., Mendrek, A. (2014). Intergenerational transmission of fronto-parietal dysfunction during forethought in attention deficit/hyperactivity disorder: a pilot study. Journal of Psychiatry Reseach:Neuroimaging, 224(3):242-5.


    Stip, E., Lungu, O.V., Anselmo, K., Letourneau, G., Mendrek, A., Stip, B., Lipp, O., Lalonde, P., Bentaleb, L. A. (2012). Neural changes associated with appetite information processing in schizophrenic patients after 16 weeks of olanzapine treatment. Transl Psychiatry 2: e128.  Pubmed

    Viveros, M. P., Mendrek, A.,  Paus, T., Lopez-Rodriguez, A. B., Marco, E. M., Yehuda, R., Cohen, H., Lehrner, A., Wagner, E. J (2012). A comparative, developmental, and clinical perspective of neurobehavioral sexual dimorphisms. Front Neurosci 6: 84.  Pubmed 

    Glaser, E., Mendrek, A., Germain, M., Lakis, N., Lavoie, M. E. (2012). Sex differences in memory of emotional images: A behavioral and electrophysiological investigation. Int J Psychophysiol.  Pubmed

    Lecardeur, L., Mendrek, A. (2012). Differentiating men and women with schizophrenia according to their cognitive profiles. Psychiatry Research 195(1-2):89.  Pubmed


    Lakis, N., Jimenez, J. A., Mancini-Marie, A., Stip, E., Lavoie, M. E., & Mendrek, A. (2011). Neural correlates of emotional recognition memory in schizophrenia: Effects of valence and arousal. Psychiatry Research, 194(3), 245-256. Pubmed

    Lecardeur, L., & Mendrek, A. (2011). Differentiating men and women with schizophrenia according to their cognitive profiles. Psychiatry research. Pubmed

    Mendrek, A., Jimenez, J. A., Mancini-Marie, A., Fahim, C., & Stip, E. (2011). Correlations between sadness-induced cerebral activations and schizophrenia symptoms: An fMRI study of sex differences. European psychiatry : the journal of the Association of European Psychiatrists, 26(5), 320-326.

    Mendrek, A., & Lakis, N. (2011). Gender differences in brain function associated with cognitive and emotion processing in schizophrenia. European Neuropsychopharmacology, 21, S204-S204. 

    Mendrek, A., Lakis, N., & Jimenez, J. (2011). Associations of sex steroid hormones with cerebral activations during mental rotation in men and women with schizophrenia. Psychoneuroendocrinology, 36 (9), 1422-1426. Pubmed

    Mendrek, A., & Stip, E. (2011). Sexual dimorphism in schizophrenia: is there a need for gender-based protocols? Expert review of neurotherapeutics, 11(7), 951-959. Pubmed


    Samson, F., Hyde, K. L., Bertone, A., Soulieres, I., Mendrek, A., Ahad, P., et al. (2010). Atypical processing of auditory temporal complexity in autistics. Neuropsychologia, 49(3), 546-555. Pubmed

    Jimenez, J. A., Mancini-Marie, A., Lakis, N., Rinaldi, M., & Mendrek, A. (2010). Disturbed sexual dimorphism of brain activation during mental rotation in schizophrenia. Schizophrenia research, 122(1-3), 53-62. Pubmed

    Lecardeur, L., Mendrek, A., & Stip, E. (2010) Sexual dimorphism of spatial working memory profiles in schizophrenia. Cognitive neuropsychiatry, 1-9. Epub ahead of print. Pubmed


    Barbeau EB, Mendrek A, Mottron L. (2009). Are autistic traits autistic? British Journal of Psychology, 100(pt 1):23-28.

    Jimenez J, Mancini-Marie A, Mendrek A. The case for not combining men and women in neurocognitive studies for schizophrenia. Schizophrenia Research. 2009 Mar;108(1-3):293-4.

    Mancini-Marie A, Cohen-Adad J, Jimenez J, Corcoran C, Rainville P, Stip E, Mendrek A, et coll. Sex Differences in Corpus Callosum Fractional Anisotropy in Schizophrenia Patients: a Pilot Tractography Study Using Diffusion Tensor Imaging. Schizophrenia Bulletin. 2009 Mar;35:210-1.

    Barbeau EB, Mendrek A, Mottron L. Are autistic traits autistic? British Journal of Psychology. 2009 Feb;100:23-8.

    Guillem F, Mendrek A, Lavoie ME, Pampoulova T, Stip E. Sex differences in memory processing in schizophrenia: An event-related potential (ERP) study. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2009 Feb;33(1):1-10.


    Domier, C. P., Simon, S., Mendrek, A., et al. (2007). "Effects of Cigarette Smoking and Abstinence on Stroop Task Performance" Psychopharmacology 195(1):1-9.

    Levaux, M. N., Potvin, S., Mendrek, A., et al. (2007). "Cognitive Assessment in Schizophrenia: Promises and Pitfalls of CANTAB." European Psychiatry 22(2):104-115.

    Mendrek, A. (2007). "Dimorphisme sexuelle dans la schizophrénie." Sante Mentale au Québec 1: 351-365.

    Mendrek, A. (2007). "Reversal of Normal Cerebral Sexual Dimorphism in Schizophrenia: Evidence and Speculations." Medical Hypothesis 69: 896-902.

    Mendrek, A., A. Mancini-Marie, et al. (2007). "Sex differences in the cerebral function associated with processing of aversive stimuli by schizophrenia patients." Australian and New Zealand Journal of Psychiatry 41: 136-141.

    Xu, J., Mendrek, A., et al. (2007). "Effects of Cigarette Smoking on Prefrontal Cortical Function in Nondeprived Smokers Performing the Stroop Task." Neuropsychopharmacology 32:1421-1428


    Bentaleb, L., Stip, E., Mendrek, A., et al. (2006). "Effet de l’écoute de mots déjà hallucinés chez des sujets schizophrènes en rémission : une étude de six cas par la résonance magnétique nucléaire fonctionnelle." L'Encephale 32: 27-40.

    Mendrek, A., J. Monterosso, et al. (2006). "Working Memory in Nonsmokers and in Cigarette Smokers during Abstinence and Relative Satiety." Addictive Behaviors 31: 833-844.


    Mendrek, A., K. Kiehl, et al. (2005). "Dysfunction of a Distributed Neural Circuitry in Schizophrenia Patients during Working Memory Performance." Psychological Medicine 35: 187-196.

    Stip, E., C. Fahim, et al. (2005). "Restoration of frontal activation during a treatment with quetiapine: an fMRI study of blunted affect in schizophrenia." Progress in Neuropsychopharmacology & Biological Psychiatry 29: 21-26.

    Stip, E., Fahim, C., Mendrek, A., et al. (2005). "Restoration of Frontal Activation During a Treatment with Quetiapine: an fMRI Study of Blunted Affect in Schizophrenia" Progress in Neuro-psychopharmacology & Biological Psychiatry 29: 21-26.

    Xu, J., Mendrek, A., et al. (2005). "Brain Activity in Cigarette Smokers Performing a Working Memory Task: Effects of Smoking Abstinence." Biological Psychiatry 58:143-150.


    Iverson, G., Mendrek, A., et al. (2004). "The Persistent Belief that VIQ-PIQ Splits Suggest Lateralized Brain Damage." Applied Neuropsychology 11: 85-90.

    Kiehl, K. A., Smith, A.M., Mendrek, A., et al. (2004). "Temporal Lobe Abnormalities in Semantic Processing by Criminal Psychopaths as Revealed by Functionnal Magnetic Resonance Imaging." Psychiatry Research: Neuroimaging 130: 27-42.

    Mendrek, A., Laurens, K., et al. (2004). "Changes in a Distributed Neural Circuitry Function in the First Episode Schizophrenic Patients during a Test-retest of a Working Memory Task." British Journal of Psychiatry 185: 205-214.