Centre intégré universitaire de santé et de services sociaux de l’Est-de-l’Île-de-Montréal
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Mottron, Laurent


Psychiatrist, Ph.D.

Institut universitaire en santé mentale de Montréal?
Research Center
Site Hôpital Rivière-des-Prairies
7070 boul. Perras
Montréal (Québec)  H1E 1A4

Phone: 514-323-7260, ext. 2173

Research areas

Neurobiology and cognition

Academic profile

Head of the Marcel & Rolande Gosselin Research Chair in Autism Cognitive Neuroscience of the Universite de Montreal

Tenured professor, Department of Psychiatry, University of Montreal and National Researcher, FRSQ.

Scientific Director of the Centre for Excellent in Pervasive and Developmental Problems at University of Montreal (CETEDUM)

Dr. Mottron is one the creative contributors of the Neurodevelopmental Problems Program at HRDP dedicated specifically to pervasive and developmental problems. He boasts over a hundred scientific publications and has delivered nearly 250 conferences around the world.

Research Interests

  • Neuropsychology of pervasive and developmental problems in the following sectors: perception of complex visual and auditory stimuli, working memory and long-term memory, calculation, attention, and intelligence profiles.
  • Developmental transformation of autistic signs ; sub-grouping human models of pervasive and developmental problems ; brain plasticity in pervasive and developmental problems ; cerebral localization in autism ; pervasive and developmental problems in identified neurological syndromes (visual agnosia, herpex simplex encephalitis, West syndrome); cognitive deficits; Savant-syndrome; precocious signs in pervasive and developmental disorders.



Merner, N., Forgeot d'Arc, B., Bell, S. C., Maussion, G., Peng, H., Gauthier, J., Crapper, L., Hamdan, F. F., Michaud, J. L., Mottron, L., Rouleau, G. A., Ernst, C. (2016). A de novo frameshift mutation in chromodomain helicase DNA-binding domain 8 (CHD8): A case report and literature review. Am J Med Genet A. Epub ahead of print. Pubmed


Hippolyte, L., Maillard, A. M., Rodriguez-Herreros, B., Pain, A., Martin-Brevet, S., Ferrari, C., Conus, P., Mace, A., Hadjikhani, N., Metspalu, A., Reigo, A., Kolk, A., Mannik, K., Barker, M., Isidor, B., Le Caignec, C., Mignot, C., Schneider, L., Mottron, L., Keren, B., David, A., Doco-Fenzy, M., Gerard, M., Bernier, R., Goin-Kochel, R. P., Hanson, E., Green Snyder, L., p11.2 European Consortium, Simons Variation in Individuals Project Consortium, Ramus, F., Beckmann, J. S., Draganski, B., Reymond, A., Jacquemont, S. (2015). The Number of Genomic Copies at the 16p11.2 Locus Modulates Language, Verbal Memory, and Inhibition. Biol Psychiatry. Epub ahead of print. Pubmed

Mottron, L. (2015). Considérations sur la place de la psychiatrie en autisme, à partir de l’histoire récente des rôles professionnels vis-a-vis de l’autisme au Québec. Sante Ment Que, 40(2), 177-190. Pubmed

Simard, I., Luck, D., Mottron, L., Zeffiro, T. A., & Soulieres, I. (2015). Autistic fluid intelligence: Increased reliance on visual functional connectivity with diminished modulation of coupling by task difficulty. Neuroimage Clin, 9, 467-478. Pubmed

Boukhris, T., Sheehy, O., Mottron, L., & Berard, A. (2015). Antidepressant Use During Pregnancy and the Risk of Autism Spectrum Disorder in Children. JAMA Pediatr, 1-8. Pubmed

Perreault, A., Habak, C., Lepore, F., Mottron, L., & Bertone, A. (2015). Behavioral evidence for a functional link between low- and mid-level visual perception in the autism spectrum. Neuropsychologia, 77, 380-386. Pubmed

Guy, J., Perreault, A., Mottron, L., & Bertone, A. (2015). A systematic examination of early perceptual influences on low-, mid and high-level visual abilities in Autism Spectrum Disorder. J Vis, 15(12), 644. Pubmed

Mottron, L.,Duret, P., Mueller, S., Moore, R. D., Forgeot d’Arc, B., Jacquemont, S., & Xiong, L. (2015). Sex differences in brain plasticity: a new hypothesis for sex ratio bias in autism. Mol Autism, 6, 33. Pubmed

Rafiq, M. A., Leblond, C. S., Saqib, M. A., Vincent, A. K., Ambalavanan, A., Khan, F. S., Ayaz, M., Shaheen, N., Spiegelman, D., Ali, G., Amin-Ud-Din, M., Laurent, S., Mahmood, H., Christian, M., Ali, N., Fennell, A., Nanjiani, Z., Egger, G., Caron, C., Waqas, A., Ayub, M., Rasheed, S., Forgeot d’Arc, B., Johnson, A., So, J., Brohi, M. Q., Mottron, L., Ansar, M., Vincent, J. B., Xiong, L. (2015). Novel VPS13B Mutations in Three Large Pakistani Cohen Syndrome Families Suggests a Baloch Variant with Autistic-Like Features. BMC Med Genet, 16, 41. Pubmed

Samson, F., Zeffiro, T. A., Doyon, J., Benali, H., & Mottron, L. (2015). Speech acquisition predicts regions of enhanced cortical response to auditory stimulation in autism spectrum individuals. J Psychiatr Res. Epub ahead of print. Pubmed

Barbeau, E. B., Meilleur, A. A., Zeffiro, T. A., & Mottron, L. (2015). Comparing Motor Skills in Autism Spectrum Individuals With and Without Speech Delay. Autism Res. Epub ahead of print. Pubmed

Morin, K., Guy, J., Habak, C., Wilson, H. R., Pagani, L., Mottron, L., & Bertone, A. (2015). Atypical Face Perception in Autism: A Point of View? Autism Res. Epub ahead of print. Pubmed

Barbeau, E. B., Lewis, J. D., Doyon, J., Benali, H., Zeffiro, T. A., & Mottron, L. (2015). A greater involvement of posterior brain areas in interhemispheric transfer in autism: fMRI, DWI and behavioral evidences. Neuroimage Clin, 8, 267-280. Pubmed


Keita, L., Guy, J., Berthiaume, C., Mottron, L., & Bertone, A. (2014). An early origin for detailed perception in Autism Spectrum Disorder: biased sensitivity for high-spatial frequency information. Sci Rep, 4, 5475. Epub ahead of print. Pubmed

Bouvet, L., Donnadieu, S., Valdois, S., Caron, C., Dawson, M., & Mottron, L. (2014). Veridical mapping in savant abilities, absolute pitch, and synesthesia: an autism case study. Front Psychol, 5, 106. Pubmed

Bouvet, L., Simard-Meilleur, A. A., Paignon, A., Mottron, L., & Donnadieu, S. (2014). Auditory local bias and reduced global interference in autism. Cognition, 131(3), 367-372. Pubmed


Rivest, J. B., Jemel, B., Bertone, A., McKerral, M., & Mottron, L. (2013). Luminance- and texture-defined information processing in school-aged children with autism. PLoS One, 8(10), e78978. Pubmed

Bouvet, L., Mottron, L., Valdois, S., & Donnadieu, S. (2013). Auditory Stream Segregation in Autism Spectrum Disorder: Benefits and Downsides of Superior Perceptual Processes. J Autism Dev Disord. Pubmed

Galle, S. A., Courchesne, V., Mottron, L., & Frasnelli, J. (2013). Olfaction in the autism spectrum. Perception, 42(3), 341-355. Pubmed

Corradi, A., Fadda, M., Piton, A., Patry, L., Marte, A., Rossi, P., Cadieux-Dion, M., Gauthier, J., Lapointe, L., Mottron, L., Valtorta, F., Rouleau, G. A., Fassio, A., Benfenati, F., Cossette, P. (2013). SYN2 is an Autism Predisposing Gene: Loss-of-function Mutations Alter Synaptic Vesicle Cycling and Axon Outgrowth. Hum Mol Genet. Epub ahead of print. Pubmed

Mottron, L., & Dawson, M. (2013). The autistic spectrum. Handb Clin Neurol, 111, 263-271. Pubmed

Limoges, E., Bolduc, C., Berthiaume, C., Mottron, L., & Godbout, R. (2013). Relationship between poor sleep and daytime cognitive performance in young adults with autism. Res Dev Disabil, 34(4), 1322-1335. Pubmed

Charbonneau, G., Bertone, A., Lepore, F., Nassim, M., Lassonde, M., Mottron, L., Collignon, O., (2013). Multilevel deficits in the processing of audio-visual emotion expressions in Autism Spectrum Disorders. Neuropsychologia. Epub ahead of print. Pubmed

Massand, E., Bowler, D. M., Mottron, L., Hosein, A., & Jemel, B. (2013). ERP Correlates of Recognition Memory in Autism Spectrum Disorder. J Autism Dev Disord. Epub ahead of print, Pubmed


Mottron, L., Bouvet, L., Bonnel, A., Samson, F., Burack, J. A., Dawson, M., Heaton, P. (2012). Veridical mapping in the development of exceptional autistic abilities. Neurosci Biobehav Rev. Epub ahead of print. Pubmed

Russo, N., Mottron, L., Burack, J. A., Jemel, B. (2012). Parameters of semantic multisensory integration depend on timing and modality order among people on the autism spectrum: Evidence from event-related potentials. Neuropsychologia 50(9): 2131-2141.

Tarabeux, J., Kebir, O., Gauthier, J., Hamdan, F. F., Xiong, L., Piton, A., Spiegelman, D., Henrion, E., Millet, B., Fathalli, F., Joober, R., Rapoport, J. L., DeLisi, L. E., Fombonne, E.,  Mottron, L., Forget-Dubois, N., Boivin, M., Michaud, J. L., Drapeau, P., Lafreniere, R. G., Rouleau, G. A., Krebs, M. O. (2012). Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia. Translational Psychiatry 1:e55. 

Forgeot d'Arc, B., Dawson, M., Soulieres, I., Mottron, L. (2012). Self-Injury in Autism is Largely Unexplained: Now What? J Autism Dev Disord. [Epub ahead of print]  Pubmed

Barbeau, E. B., Soulieres, I., Dawson, M., Zeffiro, T. A., Mottron, L. (2012). The Level and Nature of Autistic Intelligence III: Inspection Time. J Abnorm Psychol. [Epub ahead of print] Pubmed

Jemel, B., Mimeault, D., Saint-Amour, D., Mottron, L. (2012). VEP contrast sensitivity responses reveal reduced functional segregation of visual processing channels in autism. International Journal of Psychophysiology 85(3): 298-298. 

Hayward, D. A., Shore, D.I.,  Ristic, J., Kovshoff, H., Iarocci, G., Mottron, L., Burack, J. A. (2012). Flexible Visual Processing in Young Adults with Autism: The Effects of Implicit Learning on a Global-Local Task. J Autism Dev Disord.  42(11), 2383-2392.  Pubmed


Fassio, A., Patry, L., Congia, S., Onofri, F., Piton, A., Gauthier, J., Pozzi, D., Messa, M., Defranchi, E., Fadda, M., Corradi, A., Baldelli, P., Lapointe, L., St-Onge, J., Meloche, C., Mottron, L., Valtorta, F., Nguyen, D. K., Rouleau, G. A., Benfenati, F., Cossette, P. (2011). SYN1 loss-of-function mutations in ASD and partial epilepsy cause impaired synaptic function. Human molecular genetics, 20(12), 2297-2307.  Pubmed

Gauthier, J., Siddiqui, T. J., Huashan, P., Yokomaku, D., Hamdan, F. F., Champagne, N., Lapointe, M., Spiegelman, D., Noreau, A., Lafreniere, R. G., Fathalli, F., Joober, R., Krebs, M. O., Delisi, L. E., Mottron, L., Fombonne, E., Michaud, J. L., Drapeau, P., Carbonetto, S., Craig, A. M., Rouleau, G. A. (2011). Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia. Human genetics, 130(4), 563-573. Pubmed

Greffou, S., Bertone, A., Hahler, E. M., Hanssens, J. M., Mottron, L., & Faubert, J. (2011). Postural Hypo-Reactivity in Autism is Contingent on Development and Visual Environment: A Fully Immersive Virtual Reality Study. Journal of autism and developmental disorders. Pubmed

Hamdan, F. F., Daoud, H., Piton, A., Gauthier, J., Dobrzeniecka, S., Krebs, M. O., Joober, R., Lacaille, J. C., Nadeau, A., Milunsky, J. M., Wang, Z., Carmant, L., Mottron, L., Beauchamp, M. H., Rouleau, G. A., Michaud, J. L. (2011). De Novo SYNGAP1 Mutations in Nonsyndromic Intellectual Disability and Autism. Biological psychiatry, 69(9), 898-901. Pubmed

Hamdan, F. F., Gauthier, J., Dobrzeniecka, S., Lortie, A., Mottron, L., Vanasse, M., D'Anjou, G., Lacaille, J. C., Rouleau, G. A., Michaud, J. L. (2011). Intellectual disability without epilepsy associated with STXBP1 disruption. European journal of human genetics : EJHG, 19(5), 607-609. Pubmed

Keita, L., Mottron, L., Dawson, M., & Bertone, A. (2011). Atypical Lateral Connectivity: A Neural Basis for Altered Visuospatial Processing in Autism. Biological psychiatry, 70(9), 806-811. Pubmed

Mottron, L. (2011). Changing perceptions: The power of autism. Nature, 479(7371), 33-35. Pubmed

Perreault, A., Gurnsey, R., Dawson, M., Mottron, L., & Bertone, A. (2011). Increased Sensitivity to Mirror Symmetry in Autism. Plos One, 6(4). Pubmed

Samson, F., Mottron, L., Soulieres, I., & Zeffiro, T. A. (2011). Enhanced visual functioning in autism: An ALE meta-analysis. Human brain mapping. Pubmed

Soulieres, I., Dawson, M., Gernsbacher, M. A., & Mottron, L. (2011). The Level and Nature of Autistic Intelligence II: What about Asperger Syndrome? PLoS One, 6(9), e25372. Pubmed

Soulieres, I., Zeffiro, T. A., Girard, M. L., & Mottron, L. (2011). Enhanced mental image mapping in autism. Neuropsychologia, 49(5), 848-857. Pubmed


Hamdan, F. F., Daoud, H., Rochefort, D., Piton, A., Gauthier, J., Langlois, M., … Mottron, L.et al. (2010). De Novo Mutations in FOXP1 in Cases with Intellectual Disability, Autism, and Language Impairment. American journal of human genetics, 87(5), 671-678. Pubmed

Keita, L., Mottron, L., & Bertone, A. (2010). Far visual acuity is unremarkable in autism: Do we need to focus on crowding? Autism research : official journal of the International Society for Autism Research. Pubmed

Awadalla, P., Gauthier, J., Myers, R. A., Casals, F., Hamdan, F. F., Griffing, A. R., Côté, M., Henrion, E., Spiegelman, D., Tarabeux, J., Piton, A., Yang, Y., Boyko, A., Bustamante, C., Xiong, L., Rapoport, J.L., Addington, A.M., Delisi, J.L., Krebs, M.O., Joober, R., Millet, B., Fombonne, E., Mottron, L., Zilversmit, M., Keebler, J., Daoud, H., Marineau, C., Roy-Gagnon, M.H., Dubé, M.P., Eyre-Walker, A., Drapeau, P., Stone, E.A., Lafrenière, R.G., Rouleau, G.A. (2010). Direct Measure of the De Novo Mutation Rate in Autism and Schizophrenia Cohorts. American journal of human genetics. 87(3), 316-324. Pubmed

Jemel, B., Mimeault, D., Saint-Amour, D., Hosein, A., & Mottron, L. (2010). VEP contrast sensitivity responses reveal reduced functional segregation of mid and high filters of visual channels in Autism. Journal of Vision, 10(6) 13.

Mottron, L. (2010). Que fait-on de l'intelligence autistique? Enfance, 62(1), 45-57. Abstract

Soulieres, I., Hubert, B., Rouleau, N., Gagnon, L., Tremblay, P., Seron, X., Mottron, L.,. (2010). Superior estimation abilities in two autistic spectrum children. Cognitive neuropsychology, 27(3), 261-276.  Pubmed

Mitchell, P., Mottron, L., Soulieres, I., & Ropar, D. (2010). Susceptibility to the Shepard illusion in participants with autism: reduced top-down influences within perception? Autism research : official journal of the International Society for Autism Research, 3(3), 113-119. Pubmed

Piton, A., Gauthier, J., Hamdan, F. F., Lafreniere, R. G., Yang, Y., Henrion, E., Mottron, L., et al. (2010). Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia. Molecular psychiatry. 16(8), 867-880. Pubmed

Soulieres, I., Mottron, L., Giguere, G., & Larochelle, S. (2010). Category induction in autism: Slower, perhaps different, but certainly possible. Quarterly journal of experimental psychology (2006), 1-17. Pubmed

Tarabeux, J., Champagne, N., Brustein, E., Hamdan, F. F., Gauthier, J., Lapointe, M.,… Mottron, L., et al. (2010). De novo truncating mutation in kinesin 17 associated with schizophrenia. Biological Psychiatry, 68(7), 649-656. 

Bonnel, A., McAdams, S., Smith, B., Berthiaume, C., Bertone, A., Ciocca, V., Burack, J.A., Mottron, L., et al. (2010). Enhanced pure-tone pitch discrimination among persons with autism but not Asperger syndrome. Neuropsychologia, 48(9), 2465-2475. Pubmed


Barbeau EB, Mendrek A, Mottron L. (2009) Are autistic traits autistic? British Journal of Psychology. Feb;100:23-8.

Gauthier J, Spiegelman D, Piton A, Lafreniere RG, Laurent S, St-Onge J, Mottron L. et coll. (2009) Novel De Novo SHANK3 Mutation in Autistic Patients. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. Apr;150B(3):421-4.

Hamdan, F., Piton, A., Gauthier, J., Lortie, A., Dubeau, F., Dobrzeniecka, S., Mottron, L., et al. (2009). De novo STXBP1 mutations in mental retardation and nonsyndromic epilepsy. Annals of Neurology, 65(6), 748-753. Pubmed   

Hamdan FF, Gauthier J, Spiegelman D, Noreau A, Yang Y, Pellerin S, Mottron L. et coll. (2009) Mutations in SYNGAP1 in Autosomal nonsyndromic Mental Retardation. New England Journal of Medicine. Feb;360(6):599-605.

Hamdan, F., Gauthier, J., Pellerin, S., Dobrzeniecka, S., Marineau, C., Fombonne E., Mottron, L., et al. (2009). No association between SRGAP3/MEGAP haploinsufficiency and mental retardation. Archives of Neurology, 66(5), 675-676.

Hyde, K., Samson, F., Evans, A., & Mottron, L. (2009). Neuroanatomical differences in brain areas implicated in perceptual and other core features of autism revealed by cortical thickness analysis and voxel-based morphometry. Human Brain Mapping, 31(4), 556-566. - Pubmed

Mottron L, Dawson M, Soulières I. (2009). Enhanced perception in savant syndrome: patterns, structure and creativity. Philosophical Transactions of the Royal Society of London, Series B Biological Sciences, 364(1522), 1385-1391.

Piton, A., Michaud, J., Peng, H., Aradhya, S., Gauthier, J., Mottron, L., et al. (2009). Mutations in the calcium-related gene IL1RAPL1 are associated with autism. Human Molecular Genetics, 17(24), 3965-3974. Pubmed

Soulières I, D. M., Samson F, Barbeau EB, Sahyoun CP, Strangman GE, Zeffiro TA, Mottron L. (2009). Enhanced visual processing contributes to matrix reasoning in autism. Human Brain Mapping, 30(12), 4082-4107.

Weiss, L. A., Arking, D. E., Daly, M. J., & Chakravarti, A., L. Mottron (2009). A genome-wide linkage and association scan reveals novel loci for autism. Nature, 461(7265), 802-808. Pubmed 


Amiet C, Gourfinkel-An I, Bouzamondo A, Tordjman S, Baulac M, Lechat P, Mottron L. et coll. Epilepsy in autism is associated with intellectual disability and gender: Evidence from a meta-analysis. (2008) Biological Psychiatry. Oct;64(7):577-82.

Bonnel AC, McAdams S, Smith BK, Bertone A, Burack JA, Ciocca V, Mottron L.(2008) "Low Level Auditory Processing of Simple and Complex Sounds in Autism" J Acoust Soc Am. 123(5):3564.

Daoust AM, Lusignan FA, Braun CMJ, Mottron L., Godbout R. Dream content analysis in persons with an autism spectrum disorder. Journal of Autism and Developmental Disorders. 2008 Apr;38(4):634-43.

Daoust AM, Lusignan FA, Braun CMJ, Mottron L., Godbout R. (2008) EEG correlates of emotions in dream narratives from typical young adults and individuals with autistic spectrum disorders. Psychophysiology. Mar;45(2):299-308.


Dawson M, Soulières I, Gernsbacher MA, Mottron L. (2007) "The Level and Nature of Autistic Intelligence" Psychol Sci. 18(8):657-62.

Mottron L, Mineau S, Martel G, Bernier CS, Berthiaume C, Dawson M, Lemay M, Palardy S, Charman T, Faubert J. (2007) "Lateral Glances Toward Moving Stimuli Among Young Children with Autism: Early Regulation of Locally Oriented Perception?" Dev Psychopathol. 19(1):23-36.

Gras-Vincendon, A., Mottron, L., Salame, P., Bursztejn, C., & Danion, J. M. (2007). Temporal context memory in high-functioning autism. Autism, 11(6), 523-534.

Soulières I, Mottron L, Saumier D, Larochelle S. (2007) "Atypical Categorical Perception in Autism: Autonomy of Discrimination?" J Autism Dev Disord. 37(3):481-90.


Caron MJ, Mottron L, Berthiaume C, Dawson M. (2006) "Cognitive Mechanisms, Specificity and Neural Underpinnings of Visuospatial Peaks in Autism". Brain 129(Pt 7):1789-802.

Lahaie A, Mottron L, Arguin M, Berthiaume C, Jemel B, Saumier D (2006) "Face Perception in High-Functioning Autistic Adults: Evidence for Superior Processing of Face Parts, not for a Configural Face-Processing Deficit" Neuropsychology 20(1):30-41.

Mottron L, Dawson M, Soulières I, Hubert B, Burack J. (2006) "Enhanced Perceptual Functioning in Autism: An Update, and Eight Principles of Autistic Perception". J Autism Dev Disord 36(1):27-43. Review.

Gauthier J, Joober R, Dubé MP, St-Onge J, Bonnel A, Gariépy D, Laurent S, Najafee R, Lacasse H, St-Charles L, Fombonne E, Mottron L, Rouleau GA. (2006) "Autism Spectrum Disorders Associated with X Chromosome Markers in French-Canadian Males." Mol Psychiatry 11(2):206-13.


Mottron, L. (2004). L'autisme, une autre intelligence, Bruxelles, Mardaga.