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Sonia Lupien, Ph. D., Scientific Director
Fernand-Seguin Research Center
Louis-H. Lafontaine Hospital
7401 Hochelaga Street
Montreal (Quebec) H1N 3M5
Phone: 514-251-4015
Fax: 514-251-4014
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Research areas
Biological, Psychological and Social Signatures of Mental Health
Study Center
Centre for Studies on Human Stress (CSHS)
Academic profile
Ph.D. Neuroscience, Université de Montréal
Post-Doctoral Training, University of California
Post-Doctoral Training, Rockefeller University
Affiliation
Scientific Director, Fernand-Seguin Research Centre, Hospital Louis-H Lafontaine, University of Montreal
Director, Centre for Studies on Human Stress
Senior Investigator Chair on Sex, Gender and Mental Health, Canadian Institute of Gender and Health
Associate Professor, Psychiatry Department, Université de Montréal
Profile
Dr. Sonia Lupien is Scientific Director of Fernand-Seguin Research Centre of Louis–H. Lafontaine Hospital, and is an associate professor with the Department of Psychiatry at Université de Montréal. She also holds a Senior Investigator Chair on Sex, Gender and Mental Health from the Canadian Institute of Gender and Health (IGH). Dr. Lupien is also the Founder and Director of the Centre for Studies on Human Stress, whose mission it is to raise public awareness on the effects of stress on the brain and body through the use of scientifically validated data.
Dr. Lupien’s research interests focus on the effects of stress over the human lifespan. Early in her career, she showed that high levels of stress hormones in older adults are linked to both memory impairment and smaller volume of the hippocampus, a brain structure involved in learning and memory. Two years later, she showed that children from low socioeconomic status present higher levels of stress hormones when compared to children from high socioeconomic status. Importantly, Dr. Lupien’s research has demonstrated that stress may have a negative impact on humans at any age, be it young or old.
Her future projects include a research program on the detection and intervention for stress in the workplace, as well as the development of the DeStress for Success Program that aims at educating children and teenagers on stress and its impact on learning and memory. Her team is currently actively working to adapt the DeStress Program towards adults in workplace environments.
Publications
Lupien, S. J., Ouellet-Morin, I., Trepanier, L.,
Juster, R. P., Marin, M. F., Francois, N., Sindi, S., Wan, N., Findlay,
H., Durand, N., Cooper, L., Schramek, T., Andrews, J., Corbo, V.,
Dedovic, K., Lai, B., Plusquellec, P. (2013). The DeStress for
Success Program: Effects of a Stress Education Program on Cortisol
Levels and Depressive Symptomatology in Adolescents Making the
Transition to High School. Neuroscience. Epub ahead of print. Pubmed
Vachon-Presseau, E., Roy, M., Martel, M. O., Caron, E., Marin, M. F., Chen, J., Albouy, G., Plante, I., Sullivan, M. J., Lupien, S. J.,
Rainville, P. (2013). The stress model of chronic pain: evidence from
basal cortisol and hippocampal structure and function in humans. Brain, 136(Pt 3), 815-827. Pubmed
Juster, R. P., Smith, N. G., Ouellet, E., Sindi, S., & Lupien, S. J. (2013). Sexual Orientation and Disclosure in Relation to Psychiatric Symptoms, Diurnal Cortisol, and Allostatic Load Psychosom Med. Epub ahead of print. Pubmed
Sindi, S., Fiocco, A. J., Juster, R. P., Pruessner, J., & Lupien, S. J. (2013). When we test, do we stress? Impact of the testing environment on cortisol secretion and memory performance in older adults. Psychoneuroendocrinology. Epub ahead of print. Pubmed
Juster, R. P., & Lupien, S. (2012). A Sex- and Gender-Based Analysis of Allostatic Load and Physical Complaints. Gender Medicine, 9(6), 511-523. Pubmed
Arsenault-Lapierre, G., Whitehead, V., Lupien, S., Chertkow, H. (2012). Effects of anosognosia on perceived stress and cortisol levels in Alzheimer's disease. Int J Alzheimers Dis: 209570. Pubmed
Kubarych, T., Prom-Wormley, E., Franz, C., Panizzon, M., Dale, A.,
Fischl, B., Eyler, L., Fennema-Notestine, C., Grant, M., Hauger,
R., Hellhammer, D., Jak, A., Jernigan, T., Lupien, S., Lyons, M.,
Mendoza, S., Neale, M., Seidman, L., Tsuang, M., Kremen, W. (2012). A
multivariate twin study of hippocampal volume, self-esteem and
well-being in middle-aged men. Genes, Brain & Behavior 11(5): 539-544.
Marin, M. F., Morin-Major, J.K.. Schramek, T. E., Beaupre, A., Perna, A., Juster, R. P., Lupien, S. J.
(2012). There is no news like bad news: women are more remembering and
stress reactive after reading real negative news than men. PLoS One 7(10): e47189. Pubmed
Juster, R. P., Perna, A., Marin, M. F., Sindi, S., Lupien, S. J.
(2012). Timing is everything: anticipatory stress dynamics among
cortisol and blood pressure reactivity and recovery in healthy adults. Stress. 15(6), 569-577. PubMed
Sindi, S., Juster, R.P., Wan, N., Nair, N. P. V., Kin, N. Y. , Lupien, S. J. (2012). Depressive symptoms, cortisol, and cognition during human aging: The role of negative aging perceptions. Stress-the International Journal on the Biology of Stress 15(2): 130-137. Pubmed
Franz, C. E., O'Brien, R. C., Hauger, R. L., Mendoza, S. P.,
Panizzon, M. S., Prom-Wormley, E., Eaves, L. J., Jacobson, K., Lyons, M.
J., Lupien, S., Hellhammer, D., Xian, H., Kremen, W. S. (2011).
Cross-sectional and 35-year longitudinal assessment of salivary cortisol
and cognitive functioning: The Vietnam Era Twin Study of Aging. Psychoneuroendocrinology, 36(7), 1040-1052. Pubmed
Koenig, J. I., Walker, C. D., Romeo, R. D., & Lupien, S. J. (2011). Effects of stress across the lifespan. Stress, 14(5), 475-480. Pubmed
Lupien, S. J., Parent, S., Evans, A. C., Tremblay, R. E.,
Zelazo, P. D., Corbo, V., Pruessner, J. C., Seguin, J. R. (2011). Larger
amygdala but no change in hippocampal volume in 10-year-old children
exposed to maternal depressive symptomatology since birth. Proceedings of the National Academy of Sciences of the United States of America, 108(34), 14324-14329. Pubmed
Marin, M. F., Hupbach, A., Maheu, F. S., Nader, K., & Lupien, S. J. (2011). Metyrapone Administration Reduces the Strength of an Emotional Memory Trace in a Long-Lasting Manner. The Journal of clinical endocrinology and metabolism, 96(8), 221-227.
De Souza-Talarico, J. N., Marin, M.-F., Sindi, S., & Lupien, S. J. (2011). Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging. Dementia & Neuropsychologia, 5(1), 8-16. Article
Doane, L. D., Franz, C. E., Prom-Wormley, E., Eaves, L. J., Mendoza, S. P., Hellhammer, D. H., Lupien, S.,
Xian, H., Lyons, M. J., Kremen, W., Jacobson, K. C. (2011). Negative
emotionality, depressive symptoms and cortisol diurnal rhythms: Analysis
of a community sample of middle-aged males. Hormones and behavior. 60(2) 202-209 Pubmed
Franz, C. E., O'Brien, R. C., Hauger, R. L., Mendoza, S. P.,
Panizzon, M. S., Prom-Wormley, E., Eaves, L. J., Jacobson, K., Lyons, M.
J., Lupien, S., Hellhammer, D., Xian, H., Kremen, W. S. (2011).
Cross-sectional and 35-year longitudinal assessment of salivary cortisol
and cognitive functioning: The Vietnam Era Twin Study of Aging. Psychoneuroendocrinology. Pubmed
Gao, J., Leon, F., Radwan, M. M., Dale, O. R., Husni, A. S., Manly, S. P., Lupien, S.,
Wang, X., Hill, R. A., Dugan, F. M., Cutler, H. G., Cutler, S. J.
(2011). Benzyl Derivatives with in Vitro Binding Affinity for Human
Opioid and Cannabinoid Receptors from the Fungus Eurotium repens. Journal of natural products, 74(7), 1636-1639. Pubmed
Juster, R. P., Bizik, G., Picard, M., Arsenault-Lapierre, G., Sindi,
S., Trepanier, L., Marin, M. F., Wan, N., Sekerovic, Z., Lord, C.,
Fiocco, A. J., Plusquellec, P., McEwen, B. S., Lupien, S. J. (2011). A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development. Development and psychopathology, 23(3), 725-776. Pubmed
Juster, R. P., Marin, M. F., Sindi, S., Nair, N. P., Ng, Y. K., Pruessner, J. C., Lupien, S.J. (2011). Allostatic load associations to acute, 3-year and 6-year prospective depressive symptoms in healthy older adults. Physiology & behavior, 104(2), 360-364. Pubmed
Lupien, S. J. (2011). Cortisol level reveals burnout. Trac-Trends in Analytical Chemistry, 30(4), IV-V. Article
Marin, M. F., Lord, C., Andrews, J., Juster, R. P., Sindi, S., Arsenault-Lapierre, G., Fiocco, A. J., Lupien, S. J. (2011). Chronic stress, cognitive functioning and mental health. Neurobiology of learning and memory, 96(4): 583-595. Pubmed
Plusquellec, P., Ouellet-Morin, I., Feng, B., Perusse, D., Tremblay, R. E., Lupien, S. J.,
Boivin, M. (2011). Salivary cortisol levels are associated with
resource control in a competitive situation in 19month-old boys. Hormones and behavior. 60 (2) 159-164. Pubmed
Prom-Wormley, E. C., York, T. P., Jacobson, K. C., Eaves, L. J., Mendoza, S. P., Hellhammer, D., Maninger, N., Levine, S., Lupien, S.,
Lyons, M. J., Hauger, R., Xian, H., Franz, C. E., Kremen, W. S..
(2011). Genetic and environmental effects on diurnal
dehydroepiandrosterone sulfate concentrations in middle-aged men. Psychoneuroendocrinology, 36(10), 1441-1452. Pubmed
Juster, R. P., Sindi, S., Marin, M. F., Perna, A., Hashemi, A., Pruessner, J. C., Lupien, S.J. (2011). A clinical allostatic load index is associated with burnout symptoms and hypocortisolemic profiles in healthy workers. Psychoneuroendocrinology, 36(6), 797-805. Pubmed
Sindi, S., Juster, R. P., Wan, N., Nair, N. P., Ying Kin, N., & Lupien, S. J. (2011). Depressive symptoms, cortisol, and cognition during human aging: The role of negative aging perceptions. Stress. Pubmed
Juster, R. P., McEwen, B. S., & Lupien, S. J. (2010). Allostatic load biomarkers of chronic stress and impact on health and cognition. Neuroscience and Biobehavioral Reviews, 35(1), 2-16. Pubmed
Ouellet-Morin, I., Dionne, G., Lupien, S. J., Muckle, G.,
Cote, S., Perusse, D., Tremblay, R.E., Boivin, M. (2010). Prenatal
alcohol exposure and cortisol activity in 19-month-old toddlers: an
investigation of the moderating effects of sex and testosterone. Psychopharmacology. Pubmed
Lord, C., Engert, V., Lupien, S. J., & Pruessner, J. C. (2010). Effect of sex and estrogen therapy on the aging brain: a voxel-based morphometry study. Menopause (New York, N.Y.), 17(4), 846-851. Pubmed
Marin, M. F., Pilgrim, K., & Lupien, S. J. (2010). Modulatory effects of stress on reactivated emotional memories. Psychoneuroendocrinology, 35(9), 1388-1396. Pubmed
Arsenault-Lapierre, G., Chertkow, H., & Lupien, S. (2010). Seasonal effects on cortisol secretion in normal aging, mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging, 31(6), 1051-1054. Pubmed
Franz, C. E., York, T. P., Eaves, L. J., Mendoza, S. P., Hauger, R. L., Hellhammer, D. H., Lupien, S.J., et al. (2010). Genetic and Environmental Influences on Cortisol Regulation Across Days and Contexts in Middle-Aged Men. Behavior genetics, 40(4), 467-479. Pubmed
Therrien, F., Drapeau, V., Lalonde, J., Lupien, S. J.,
Beaulieu, S., Dore, J., et al. (2010). Cortisol response to the Trier
Social Stress Test in obese and reduced obese individuals. Biological psychology, 84(2), 325-329. Pubmed
Wadiwalla, M., Andrews, J., Lai, B., Buss, C., Lupien, S. J.,
& Pruessner, J. C. (2010). Effects of manipulating the amount of
social-evaluative threat on the cortisol stress response in young
healthy women. Stress (Amsterdam, Netherlands), 13(3), 214-220. Pubmed
Doane, L. D., Kremen, W. S., Eaves, L. J., Eisen, S. A., Hauger, R., Hellhammer, D., Lupien, S.J., et al. (2010) Associations between jet lag and cortisol diurnal rhythms after domestic travel. Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 29(2), 117-123. Pubmed
Kremen, W. S., O'Brien, R. C., Panizzon, M. S., Prom-Wormley, E., Eaves, L. J., Eisen, S. A., Lupien S.J., et al. (2010) Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study. NeuroImage. 53(3) 1093-1102. Pubmed
Viau, R., Arsenault-Lapierre, G., Fecteau, S., Champagne, N., Walker, C. D., & Lupien, S. (2010). Effect of service dogs on salivary cortisol secretion in autistic children. Psychoneuroendocrinology, 35(8), 1187-1193. Pubmed
Brenner, K., Liu, A., Laplante, D.P., Lupien, S., Pruessner,
J.C., Ciampi, A., Joober, R., King, S. (2009) Cortisol response to a
psychosocial stressor in schizophrenia: Blunted, delayed, or normal? Psychoneuroendocrinology, Feb. 3, Epub ahead of Print.
Hebert, S., & Lupien, S. J. (2009). Salivary cortisol
levels, subjective stress, and tinnitus intensity in tinnitus sufferers
during noise exposure in the laboratory. International Journal of Hygiene and Environmental Health, 212(1), 37-44.
Lord, C., Duchesne, A., Pruessner, J. C., & Lupien, S. J. (2009). Measuring indices of lifelong estrogen exposure: self-report reliability. Climacteric, 12(5), 387-394. Pubmed
Lupien, S. J. (2009). Brains Under Stress. Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie, 54(1), 4-5.
Lupien, S.J., McEwen, B.S., Gunnar, M.R., Heim, C. (2009). Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nature Reviews - Neurosciences, Apr. 29, Epub ahead of print.
Panizzon, M., Dale, A., Eaves, L., Eisen, S., Fennema-Notestine, C., Franz, C., Lupien, S., et al. (2009). Moderating effects of testosterone on the genetic and environmental components of hippocampal volume. Behavior Genetics, 39(6), 674-675.
Pilgrim, K., Marin, M. F., & Lupien, S. J. (2009).
Attentional orienting toward social stress stimuli predicts increased
cortisol responsivity to psychosocial stress irrespective of the early
socioeconomic status. Psychoneuroendocrinology, 35(4), 588-595. - Pubmed
Pruessner, J., K. Dedovic, Lupien, S., J., et al. (2009).
"Stress regulation in the central nervous system: evidence from
structural and functional neuroimaging studies in human populations -
2008 Curt Richter Award Winner." Psychoneuroendocrinology, 35(1): 179-191. - Pubmed
Souza-Talarico, J. N., Chaves, E. C., Lupien, S. J., Nitrini,
R., & Caramelli, P. Relationship between cortisol levels and memory
performance may be modulated by the presence or absence of cognitive
impairment: evidence from healthy elderly, mild cognitive impairment and
Alzheimer's disease subjects. Journal of Alzheimer's disease : JAD, 19(3), 839-848. Pubmed
Lord, C., Buss, C., Lupien, S. J., & Pruessner, J. C.
(2008). Hippocampal volumes are larger in postmenopausal women using
estrogen therapy compared to past users, never users and men: A possible
window of opportunity effect. Neurobiology of Aging, 29(1), 95-101.
Ouellet-Morin, I., Boivin, M., Dionne, G., Lupien, S. J.,
Arsenault, L., Barr, R. G., et al. (2008). Variations in heritability of
cortisol reactivity to stress as a function of early familial adversity
among 19-month-old twins. Archives of General Psychiatry, 65(2), 211-218.
Fiocco, A. J., Poirier, J., Joober, R., Nair, N. P. V., & Lupien, S. J.
(2008). Acute and long-term associations between ApoE genetic
polymorphism, cortisol levels, and declarative memory performance in
older adults. Psychoneuroendocrinology, 33(5), 625-633.
Lord, C., Buss, C., Lupien, S. J., & Pruessner, J. C.
(2008). Hippocampal volumes are larger in postmenopausal women using
estrogen therapy compared to past users, never users and men: A possible
window of opportunity effect. Neurobiology of Aging, 29(1), 95-101.
Ouellet-Morin, I., Boivin, M., Dionne, G., Lupien, S. J.,
Arsenault, L., Barr, R. G., et al. (2008). Variations in heritability of
cortisol reactivity to stress as a function of early familial adversity
among 19-month-old twins. Archives of General Psychiatry, 65(2), 211-218.
Pruessner, J. C., Dedovic, K., Lupien, S.J., et al. (2008).
"Deactivation of the Limbic System during Acute Psychosocial Stress:
Evidence from Positron Emission Tomography and Functional Magnetic
Resonance Imaging Studies." Biological Psychiatry, 63(2): 234-40.
Therrien, F., Drapeau, V., Lupien, S.J., et al. (2008). "Awakening Cortisol Response in Relation to Psychosocial Profiles and Eating Behaviors." Physiology & Behavior, 93(1-2): 282-8.
Weekes, N. Y., Lewis, R. S., Goto, S. G., Garrison-Jakel, J., Patel, F., & Lupien, S. (2008). The effect of an environmental stressor on gender differences on the awakening cortisol response. Psychoneuroendocrinology, 33(6), 766-772.
Wrosch, C., Miller, G. E., Lupien, S., & Pruessner, J. C.
(2008). Diurnal Cortisol Secretion and 2-Year Changes in Older Adults'
Physical Symptoms: The Moderating Roles of Negative Affect and Sleep. Health Psychology, 27(6), 685-693.
Andrews, J., Wadiwalla, M., Lupien, S.J., et al. (2007).
"Effects of Manipulating the Amount of Social-Evaluative Threat on the
Cortisol Stress Response in Young Healthy Men." Behavioral Neuroscience 121(5): 871-6.
Buss, C., C. Lord, Lupien, S.J., et al. (2007). "Maternal Care
Modulates the Relationship between Rrenatal Risk and Hippocampal Volume
in Women but not in Men." Journal of Neuroscience, 27(10): 2592-5.
Fiocco, A. J., R. Joober, Lupien, S.J., et al. (2007). "Education
Modulates Cortisol Reactivity to the Trier Social Stress Test in
Middle-Aged Adults." Psychoneuroendocrinology, 32(8-10): 1158-63.
Hebert, S., Lupien, S.J. (2007). "The Sound of Stress: Blunted Cortisol Reactivity to Psychosocial Stress in Tinnitus Sufferers." Neuroscience Letters, 411(2): 138-42.
Lupien, S. J., A. Evans, et al. (2007). "Hippocampal Volume is
as Variable in Young as in Older Adults: Implications for the Notion of
Hippocampal Atrophy in Humans." Neuroimage, 34(2): 479-85.
Lupien, S. J., Maheu, F., et al. (2007). "The Effects of
Stress and Stress Hormones on Human Cognition: Implications for the
Field of Brain and Cognition." Brain & Cognition, 65(3): 209-37.
Pruessner, M., Pruessner, J.C., Lupien, S.J., et al. (2007). "The Associations among Hippocampal Volume, Cortisol Reactivity, and Memory Performance in Healthy Young Men." Psychiatry Research, 155(1): 1-10.