Lupien, Sonia

Ph. D. en neurosciences Professeure titulaire, Département de psychiatrie, Faculté de médecine, Université de Montréal Directrice scientifique, Centre de recherche de l'Institut universitaire en santé mentale de Montréal Directrice, Centre d'études sur le stress humain Tél. : 514 251-4000 slupien.iusmm@ssss.gouv.qc.ca

Visionnez sa conférence Le stress des enfants et des adolescents en webdiffusion via Livestream 

Axe de recherche

Neurobiologie et cognition

Thèmes de recherche

Stress – Cortisol - Psychoneuroendocrinologie - Cognition

Profil

Sonia Lupien est directrice scientifique du centre de recherche de l’Institut universitaire en santé mentale de Montréal. Elle s’intéresse aux effets du stress au cours d’une vie et a mené des études chez les enfants et les jeunes adultes. Ses études ont démontré que même les enfants sont vulnérables aux effets du stress, et que certains sécrètent des taux élevés d’hormones dès l’âge de 6 ans. Ses études chez les jeunes adultes l’ont menée à démontrer les effets aigus et chroniques des hormones de stress sur la mémoire et la régulation des émotions. Enfin, ses études sur les populations âgées ont permis de démontrer les effets néfastes du stress chronique sur l’hippocampe, une région impliquée dans l’apprentissage et la mémoire.

Dans le cadre de ses nouveaux projets de recherche, elle s’intéresse aux différences hommes/femmes quant à la réactivité au stress et à ses effets sur la mémoire et la régulation des émotions. Elle a mis sur pied le programme Dé-Stresse et Progresse pour donner des moyens aux enfants de faire la transition entre l’école primaire et l’école secondaire, une période au cours de laquelle les enfants sont grandement vulnérables au stress. Son équipe travaille maintenant à l’adapter pour les adultes en milieu de travail. Elle est titulaire de la Chaire sur la santé mentale des hommes et des femmes des Instituts canadiens de la santé des hommes et des femmes. Elle est aussi la fondatrice et directrice du Centre d’Études sur le stress humain qui a pour mission d’éduquer le public sur les effets du stress sur le cerveau et le corps en utilisant des données validées scientifiquement.

Bourses et distinctions

• Développement du programme ‘Dé-Stresse et Progresse’: Programme éducatif sur le stress des adolescents destiné à Facebook (chercheure principale, Fondation Québécoise des Maladies Mentales, 2011-2012)
• The Association Between Socioeconomic Status and Health : A Socio- Biological Study (chercheure principale, MacArthur Foundation, USA, 2011-2013)
• When We Test, We Do Stress Older Adults : Transferring this Knowledge to Increase Health Care (chercheure principale, IRSC, 2011-2012)
• Silent Victims : Stigma Surrounding the Mentally Ill and Stress Effects on Spouses and Their Children (chercheure principale, IRSC, 2010-2015)
• A Sex & Gender Based Analysis of the Effects of Chronic Stress on Physiological and Psychological Determinants of Health in Workers (chercheure principale, IRSC, 2010-2015
• Biomarkers of Stress and Allostatic Load and Association with Mental Health in Humans (chercheure principale, Canadian Foundation for Innovation, 2010-2015)
• Titulaire de la Chaire en santé mentale des femmes et des hommes de l’Institut de santé des femmes et des hommes des Instituts de recherche en santé du Canada (IRSC, 2008-2013)
• Stress-induced vulnerability to depression during adolescence: Evaluating the efficacy of the DeStress for Success Program (chercheure principale, National Alliance for Research on Schizophrenia And Depression, 2008-2010)
• Genes X Stress Interactions: Effects on Human Memory (chercheure principale, IRSC, 2007-2012)
• Chercheur boursier (IRSC, 2003-2008)
• Chercheur Boursier Senior (FRQS, 2003-2007)

Distinctions

• Nommée à titre de «Top 10 Canadians who make a difference» par la revue MacLean’s (2003)
• Prix «Canada’s Top 40 Under 40 Award» (2002)
• Nommée l’une des «50 jeunes personnalités les plus importantes de l'année 2000» par Radio-Canada (Le Point) et la revue Commerce (2000)

Publications

Lupien, S. J. (2014). The Double-Hit Effect of Childhood Maltreatment on Drug Relapse. JAMA Psychiatry. Epub ahead of print. Epub ahead of print. Pubmed

Marchand, A., Juster, R. P., Durand, P., & Lupien, S. J. (2014). Burnout symptom sub-types and cortisol profiles: What's burning most? Psychoneuroendocrinology, 40, 27-36. Pubmed

De Beaumont, L., Fiocco, A. J., Quesnel, G., Lupien, S., & Poirier, J. (2013). Altered declarative memory in introverted middle-aged adults carrying the BDNF val66met allele. Behav Brain Res Epub ahead of print. Pubmed

Pelletier, J. F.. , Rowe, M., Francois, N., Bordeleau, J., & Lupien, S. (2013). No personalization without participation: on the active contribution of psychiatric patients to the development of a mobile application for mental health. BMC Med Inform Decis Mak, 13 , 78. Pubmed

Bizik, G., Picard, M., Nijjar, R., Tourjman, V., McEwen, B. S., Lupien, S. J., & Juster, R. P. (2013). Allostatic load as a tool for monitoring physiological dysregulations and comorbidities in patients with severe mental illnesses. Harv Rev Psychiatry, 21(6), 296-313. Pubmed

Trepanier, L., Juster, R. P., Marin, M. F., Plusquellec, P., Francois, N., Sindi, S., Wan, N., Findlay, H., Schramek, T., Andrews, J., Corbo, V., Dedovic, K., Lupien, S. (2013). Early menarche predicts increased depressive symptoms and cortisol levels in Quebec girls ages 11 to 13. Dev Psychopathol, 25(4 Pt 1), 1017-1027. Pubmed

Pelletier, J. F., Rowe, M., Francois, N., Bordeleau, J., & Lupien, S. (2013). No personalization without participation: on the active contribution of psychiatric patients to the development of a mobile application for mental health. BMC Med Inform Decis Mak, 13, 78. Pubmed

De Beaumont, L., Fiocco, A. J., Quesnel, G., Lupien, S., & Poirier, J. (2013). Altered declarative memory in introverted middle-aged adults carrying the BDNF val66met allele. Behav Brain Res. Epub ahead of print. Pubmed

Franz, C. E., Spoon, K., Thompson, W., Hauger, R. L., Hellhammer, D. H., Jacobson, K. C., Lupien, S., Lyons, M. J., McCaffery, J., McKenzie, R., Mendoza, S. P., Panizzon, M. S., Ramundo, A., Shahroudi, A., Kremen, W. S. (2013). Adult cognitive ability and socioeconomic status as mediators of the effects of childhood disadvantage on salivary cortisol in aging adults. Psychoneuroendocrinology. Epub ahead of print. Pubmed

Vachon-Presseau, E., Martel, M. O., Roy, M., Caron, E., Albouy, G., Marin, M. F., Plante, I., Sullivan, M. J., Lupien, S. J., Rainville, P. (2013). Acute Stress Contributes to Individual Differences in Pain and Pain-Related Brain Activity in Healthy and Chronic Pain Patients. J Neurosci, 33(16), 6826-6833. Pubmed

Lupien, S. J., Ouellet-Morin, I., Trepanier, L., Juster, R. P., Marin, M. F., Francois, N., Sindi, S., Wan, N., Findlay, H., Durand, N., Cooper, L., Schramek, T., Andrews, J., Corbo, V., Dedovic, K., Lai, B., Plusquellec, P. (2013). The DeStress for Success Program: Effects of a Stress Education Program on Cortisol Levels and Depressive Symptomatology in Adolescents Making the Transition to High School. Neuroscience. Epub ahead of print. Pubmed

Vachon-Presseau, E., Roy, M., Martel, M. O., Caron, E., Marin, M. F., Chen, J., Albouy, G., Plante, I., Sullivan, M. J., Lupien, S. J., Rainville, P. (2013). The stress model of chronic pain: evidence from basal cortisol and hippocampal structure and function in humans. Brain, 136(Pt 3), 815-827. Pubmed

Juster, R. P., Smith, N. G., Ouellet, E., Sindi, S., & Lupien, S. J. (2013). Sexual Orientation and Disclosure in Relation to Psychiatric Symptoms, Diurnal Cortisol, and Allostatic Load Psychosom Med. Epub ahead of print. Pubmed

Sindi, S., Fiocco, A. J., Juster, R. P., Pruessner, J., & Lupien, S. J. (2013). When we test, do we stress? Impact of the testing environment on cortisol secretion and memory performance in older adults. Psychoneuroendocrinology. Epub ahead of print. Pubmed

Juster, R. P., & Lupien, S. (2012). A Sex- and Gender-Based Analysis of Allostatic Load and Physical Complaints. Gender Medicine, 9(6), 511-523. Pubmed

Arsenault-Lapierre, G., Whitehead, V., Lupien, S., Chertkow, H. (2012). Effects of anosognosia on perceived stress and cortisol levels in Alzheimer's disease. Int J Alzheimers Dis: 209570. Pubmed

Kubarych, T., Prom-Wormley, E., Franz, C., Panizzon, M., Dale, A., Fischl, B., Eyler, L., Fennema-Notestine, C.,  Grant, M., Hauger, R., Hellhammer, D., Jak, A., Jernigan, T., Lupien, S., Lyons, M., Mendoza, S., Neale, M., Seidman, L., Tsuang, M., Kremen, W. (2012). A multivariate twin study of hippocampal volume, self-esteem and well-being in middle-aged men. Genes, Brain & Behavior 11(5): 539-544.

Marin, M. F., Morin-Major, J.K.. Schramek, T. E., Beaupre, A., Perna, A., Juster, R. P., Lupien, S. J. (2012). There is no news like bad news: women are more remembering and stress reactive after reading real negative news than men. PLoS One 7(10): e47189.  Pubmed

Juster, R. P., Perna, A., Marin, M. F., Sindi, S., Lupien, S. J. (2012). Timing is everything: anticipatory stress dynamics among cortisol and blood pressure reactivity and recovery in healthy adults. Stress.  15(6), 569-577. PubMed

Sindi, S., Juster, R.P., Wan, N., Nair, N. P. V., Kin, N. Y. , Lupien, S. J. (2012). Depressive symptoms, cortisol, and cognition during human aging: The role of negative aging perceptions. Stress-the International Journal on the Biology of Stress 15(2): 130-137.  Pubmed

Franz, C. E., O'Brien, R. C., Hauger, R. L., Mendoza, S. P., Panizzon, M. S., Prom-Wormley, E., Eaves, L. J., Jacobson, K., Lyons, M. J., Lupien, S., Hellhammer, D., Xian, H., Kremen, W. S. (2011). Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: The Vietnam Era Twin Study of Aging. Psychoneuroendocrinology, 36(7), 1040-1052. Pubmed

Koenig, J. I., Walker, C. D., Romeo, R. D., & Lupien, S. J. (2011). Effects of stress across the lifespan. Stress, 14(5), 475-480. Pubmed

Lupien, S. J., Parent, S., Evans, A. C., Tremblay, R. E., Zelazo, P. D., Corbo, V., Pruessner, J. C., Seguin, J. R. (2011). Larger amygdala but no change in hippocampal volume in 10-year-old children exposed to maternal depressive symptomatology since birth. Proceedings of the National Academy of Sciences of the United States of America, 108(34), 14324-14329. Pubmed

Marin, M. F., Hupbach, A., Maheu, F. S., Nader, K., & Lupien, S. J. (2011). Metyrapone Administration Reduces the Strength of an Emotional Memory Trace in a Long-Lasting Manner. The Journal of clinical endocrinology and metabolism, 96(8), 221-227.

De Souza-Talarico, J. N., Marin, M.-F., Sindi, S., & Lupien, S. J. (2011). Effects of stress hormones on the brain and cognition: Evidence from normal to pathological aging. Dementia & Neuropsychologia, 5(1), 8-16. Article

Doane, L. D., Franz, C. E., Prom-Wormley, E., Eaves, L. J., Mendoza, S. P., Hellhammer, D. H., Lupien, S., Xian, H., Lyons, M. J., Kremen, W., Jacobson, K. C. (2011). Negative emotionality, depressive symptoms and cortisol diurnal rhythms: Analysis of a community sample of middle-aged males. Hormones and behavior. 60(2) 202-209 Pubmed

Franz, C. E., O'Brien, R. C., Hauger, R. L., Mendoza, S. P., Panizzon, M. S., Prom-Wormley, E., Eaves, L. J., Jacobson, K., Lyons, M. J., Lupien, S., Hellhammer, D., Xian, H., Kremen, W. S. (2011). Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: The Vietnam Era Twin Study of Aging. Psychoneuroendocrinology. Pubmed

Gao, J., Leon, F., Radwan, M. M., Dale, O. R., Husni, A. S., Manly, S. P., Lupien, S., Wang, X., Hill, R. A., Dugan, F. M., Cutler, H. G., Cutler, S. J. (2011). Benzyl Derivatives with in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors from the Fungus Eurotium repens. Journal of natural products, 74(7), 1636-1639. Pubmed

Juster, R. P., Bizik, G., Picard, M., Arsenault-Lapierre, G., Sindi, S., Trepanier, L., Marin, M. F., Wan, N., Sekerovic, Z., Lord, C., Fiocco, A. J., Plusquellec, P., McEwen, B. S., Lupien, S. J. (2011). A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development. Development and psychopathology, 23(3), 725-776. Pubmed

Juster, R. P., Marin, M. F., Sindi, S., Nair, N. P., Ng, Y. K., Pruessner, J. C., Lupien, S.J. (2011). Allostatic load associations to acute, 3-year and 6-year prospective depressive symptoms in healthy older adults. Physiology & behavior, 104(2), 360-364. Pubmed

Marin, M. F., Lord, C., Andrews, J., Juster, R. P., Sindi, S., Arsenault-Lapierre, G., Fiocco, A. J., Lupien, S. J. (2011). Chronic stress, cognitive functioning and mental health. Neurobiology of learning and memory, 96(4): 583-595. Pubmed

Plusquellec, P., Ouellet-Morin, I., Feng, B., Perusse, D., Tremblay, R. E., Lupien, S. J., Boivin, M. (2011). Salivary cortisol levels are associated with resource control in a competitive situation in 19month-old boys. Hormones and behavior. 60 (2) 159-164. Pubmed

Prom-Wormley, E. C., York, T. P., Jacobson, K. C., Eaves, L. J., Mendoza, S. P., Hellhammer, D., Maninger, N., Levine, S., Lupien, S., Lyons, M. J., Hauger, R., Xian, H., Franz, C. E., Kremen, W. S.. (2011). Genetic and environmental effects on diurnal dehydroepiandrosterone sulfate concentrations in middle-aged men. Psychoneuroendocrinology, 36(10), 1441-1452. Pubmed

Juster, R. P., Sindi, S., Marin, M. F., Perna, A., Hashemi, A., Pruessner, J. C., Lupien, S.J. (2011). A clinical allostatic load index is associated with burnout symptoms and hypocortisolemic profiles in healthy workers. Psychoneuroendocrinology, 36(6), 797-805. Pubmed

Sindi, S., Juster, R. P., Wan, N., Nair, N. P., Ying Kin, N., & Lupien, S. J. (2011). Depressive symptoms, cortisol, and cognition during human aging: The role of negative aging perceptions. Stress. Pubmed

Juster, R. P., McEwen, B. S., & Lupien, S. J. (2010). Allostatic load biomarkers of chronic stress and impact on health and cognition. Neuroscience and Biobehavioral Reviews, 35(1), 2-16. Pubmed

Ouellet-Morin, I., Dionne, G., Lupien, S. J., Muckle, G., Cote, S., Perusse, D., Tremblay, R.E., Boivin, M. (2010). Prenatal alcohol exposure and cortisol activity in 19-month-old toddlers: an investigation of the moderating effects of sex and testosterone. Psychopharmacology. Pubmed

Lord, C., Engert, V., Lupien, S. J., & Pruessner, J. C. (2010). Effect of sex and estrogen therapy on the aging brain: a voxel-based morphometry study. Menopause (New York, N.Y.), 17(4), 846-851. Pubmed

Marin, M. F., Pilgrim, K., & Lupien, S. J. (2010). Modulatory effects of stress on reactivated emotional memories. Psychoneuroendocrinology, 35(9), 1388-1396. Pubmed

Arsenault-Lapierre, G., Chertkow, H., & Lupien, S. (2010). Seasonal effects on cortisol secretion in normal aging, mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging, 31(6), 1051-1054. Pubmed

Franz, C. E., York, T. P., Eaves, L. J., Mendoza, S. P., Hauger, R. L., Hellhammer, D. H., Lupien, S.J., et al. (2010). Genetic and Environmental Influences on Cortisol Regulation Across Days and Contexts in Middle-Aged Men. Behavior genetics, 40(4), 467-479. Pubmed

Therrien, F., Drapeau, V., Lalonde, J., Lupien, S. J., Beaulieu, S., Dore, J., et al. (2010). Cortisol response to the Trier Social Stress Test in obese and reduced obese individuals. Biological psychology, 84(2), 325-329.  Pubmed

Wadiwalla, M., Andrews, J., Lai, B., Buss, C., Lupien, S. J., & Pruessner, J. C. (2010). Effects of manipulating the amount of social-evaluative threat on the cortisol stress response in young healthy women. Stress (Amsterdam, Netherlands), 13(3), 214-220. Pubmed

Doane, L. D., Kremen, W. S., Eaves, L. J., Eisen, S. A., Hauger, R., Hellhammer, D., Lupien, S.J., et al. (2010) Associations between jet lag and cortisol diurnal rhythms after domestic travel. Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 29(2), 117-123. Pubmed

Kremen, W. S., O'Brien, R. C., Panizzon, M. S., Prom-Wormley, E., Eaves, L. J., Eisen, S. A., Lupien S.J., et al. (2010) Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study. NeuroImage. 53(3) 1093-1102. Pubmed

Viau, R., Arsenault-Lapierre, G., Fecteau, S., Champagne, N., Walker, C. D., & Lupien, S. (2010). Effect of service dogs on salivary cortisol secretion in autistic children. Psychoneuroendocrinology, 35(8), 1187-1193. Pubmed

Brenner, K., Liu, A., Laplante, D.P., Lupien, S., Pruessner, J.C., Ciampi, A., Joober, R., King, S. (2009) Cortisol response to a psychosocial stressor in schizophrenia: Blunted, delayed, or normal? Psychoneuroendocrinology, Feb. 3, Epub ahead of Print.

Hebert, S., & Lupien, S. J. (2009). Salivary cortisol levels, subjective stress, and tinnitus intensity in tinnitus sufferers during noise exposure in the laboratory. International Journal of Hygiene and Environmental Health, 212(1), 37-44. 

Lord, C., Duchesne, A., Pruessner, J. C., & Lupien, S. J. (2009). Measuring indices of lifelong estrogen exposure: self-report reliability. Climacteric, 12(5), 387-394.  Pubmed

Lupien, S. J. (2009). Brains Under Stress. Canadian Journal of Psychiatry-Revue Canadienne De Psychiatrie, 54(1), 4-5.

Lupien, S.J., McEwen, B.S., Gunnar, M.R., Heim, C. (2009). Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nature Reviews - Neurosciences, Apr. 29, Epub ahead of print.

Pilgrim, K., Marin, M. F., & Lupien, S. J. (2009). Attentional orienting toward social stress stimuli predicts increased cortisol responsivity to psychosocial stress irrespective of the early socioeconomic status. Psychoneuroendocrinology, 35(4), 588-595. - Pubmed 

Pruessner, J., K. Dedovic, Lupien, S., J., et al. (2009). "Stress regulation in the central nervous system: evidence from structural and functional neuroimaging studies in human populations - 2008 Curt Richter Award Winner." Psychoneuroendocrinology, 35(1): 179-191. - Pubmed

Souza-Talarico, J. N., Chaves, E. C., Lupien, S. J., Nitrini, R., & Caramelli, P. Relationship between cortisol levels and memory performance may be modulated by the presence or absence of cognitive impairment: evidence from healthy elderly, mild cognitive impairment and Alzheimer's disease subjects. Journal of Alzheimer's disease : JAD, 19(3), 839-848. Pubmed

Lord, C., Buss, C., Lupien, S. J., & Pruessner, J. C. (2008). Hippocampal volumes are larger in postmenopausal women using estrogen therapy compared to past users, never users and men: A possible window of opportunity effect. Neurobiology of Aging, 29(1), 95-101.

Ouellet-Morin, I., Boivin, M., Dionne, G., Lupien, S. J., Arsenault, L., Barr, R. G., et al. (2008). Variations in heritability of cortisol reactivity to stress as a function of early familial adversity among 19-month-old twins. Archives of General Psychiatry, 65(2), 211-218.

Fiocco, A. J., Poirier, J., Joober, R., Nair, N. P. V., & Lupien, S. J. (2008). Acute and long-term associations between ApoE genetic polymorphism, cortisol levels, and declarative memory performance in older adults. Psychoneuroendocrinology, 33(5), 625-633.

Lord, C., Buss, C., Lupien, S. J., & Pruessner, J. C. (2008). Hippocampal volumes are larger in postmenopausal women using estrogen therapy compared to past users, never users and men: A possible window of opportunity effect. Neurobiology of Aging, 29(1), 95-101.

Ouellet-Morin, I., Boivin, M., Dionne, G., Lupien, S. J., Arsenault, L., Barr, R. G., et al. (2008). Variations in heritability of cortisol reactivity to stress as a function of early familial adversity among 19-month-old twins. Archives of General Psychiatry, 65(2), 211-218.

Pruessner, J. C., Dedovic, K., Lupien, S.J., et al. (2008). "Deactivation of the Limbic System during Acute Psychosocial Stress: Evidence from Positron Emission Tomography and Functional Magnetic Resonance Imaging Studies." Biological Psychiatry, 63(2): 234-40.

Therrien, F., Drapeau, V., Lupien, S.J., et al. (2008). "Awakening Cortisol Response in Relation to Psychosocial Profiles and Eating Behaviors." Physiology & Behavior, 93(1-2): 282-8.

Weekes, N. Y., Lewis, R. S., Goto, S. G., Garrison-Jakel, J., Patel, F., & Lupien, S. (2008). The effect of an environmental stressor on gender differences on the awakening cortisol response. Psychoneuroendocrinology, 33(6), 766-772.

Wrosch, C., Miller, G. E., Lupien, S., & Pruessner, J. C. (2008). Diurnal Cortisol Secretion and 2-Year Changes in Older Adults' Physical Symptoms: The Moderating Roles of Negative Affect and Sleep. Health Psychology, 27(6), 685-693.

Andrews, J., Wadiwalla, M., Lupien, S.J., et al. (2007). "Effects of Manipulating the Amount of Social-Evaluative Threat on the Cortisol Stress Response in Young Healthy Men." Behavioral Neuroscience 121(5): 871-6.

Buss, C., C. Lord, Lupien, S.J., et al. (2007). "Maternal Care Modulates the Relationship between Rrenatal Risk and Hippocampal Volume in Women but not in Men." Journal of Neuroscience, 27(10): 2592-5.

Fiocco, A. J., R. Joober, Lupien, S.J., et al. (2007). "Education Modulates Cortisol Reactivity to the Trier Social Stress Test in Middle-Aged Adults." Psychoneuroendocrinology, 32(8-10): 1158-63.

Hebert, S., Lupien, S.J. (2007). "The Sound of Stress: Blunted Cortisol Reactivity to Psychosocial Stress in Tinnitus Sufferers." Neuroscience Letters, 411(2): 138-42.

Lupien, S. J., A. Evans, et al. (2007). "Hippocampal Volume is as Variable in Young as in Older Adults: Implications for the Notion of Hippocampal Atrophy in Humans." Neuroimage, 34(2): 479-85.

Lupien, S. J., Maheu, F., et al. (2007). "The Effects of Stress and Stress Hormones on Human Cognition: Implications for the Field of Brain and Cognition." Brain & Cognition, 65(3): 209-37.

Pruessner, M., Pruessner, J.C., Lupien, S.J., et al. (2007). "The Associations among Hippocampal Volume, Cortisol Reactivity, and Memory Performance in Healthy Young Men." Psychiatry Research, 155(1): 1-10.